KMID : 0605620040110020088
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Journal of Korean Society of Biological Psychiatry 2004 Volume.11 No. 2 p.88 ~ p.93
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An Association Study of the 5-HTTLPR and COMT Genes Polymorphisms and Personality Traits
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Ha Jee-Hyun
Ham Byung-Joo Ryu Seong-Gon Hwang Tae-Yeon Lee Jong-Gook Lee Yu-Sang Lee Jung-Sik Kang Dae-Yeob Choi Ihn-Geun Lee Min-Soo
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Abstract
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Background£ºSerotonin transporter gene-linked polymorphism region(5-HTTLPR) and catechol-O-methyl-transferase(COMT) genes are thought to be important factors in some personality traits and the etiology of anxiety disorder. The goal of this study was to determine the role of these genes in personality traits.
Method£ºThe participants included 116 healthy adults with no history of psychiatric disorders and other physical illness for the last 6 months. All participants were tested by Temperament and Character Inventory(TCI). The 5-HTTLPR, COMT val158met gene polymorphisms were analyzed with PCR(Polymerase Chain Reaction). Differ-ences on TCI dimensions and sub-scales among groups were examined with t-test and ANOVA.
Result£ºThere were possible relationships of the 5-HTTLPR with self-transcendence(P=0.050) and COMT val158met polymorphism with cooperativeness(P=0.053).
Conclusion£ºWe found associations between 5-HTTLPR, COMT polymorphisms and the some TCI character dimensions. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.
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KEYWORD
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Temperament and Character Inventory, 5-HTTLPR, COMT, Personality traits, Genetic polymorphism
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